SAVED
File name .JPG
File alt. text
Image should be px wide x px tall.
Select Image
home - Stomach - Gastritis and Gastropathy - Haemorrhagic Gastritis Written by Dr Sebastian Zeki

Haemorrhagic Gastritis

Acute hemorrhagic erosive gastropathy The hallmark of acute hemorrhagic and erosive gastropathy is the develop-ment of hemorrhagic and erosive lesions Mechanisms of Injury:The normal protective barrier (which includes secreted mucins, bicarbonate, and the epithelium itself) is disrupted.An additional specific pathogenetic factor in NSAID-induced acute hemorrhagic and erosive gastropathy is the inhibition of prostaglandin production. AcidBile acidsProteases Factors Damaging the Surface epithelium: NSAIDs.Alcohol.Bile acids.Mucosal hypoxia(burns, trauma, sepsis).Chemotherapy. Stress-related lesions (Curling's ulcers): Ulcers are: MultipleShallowMeasure 0.5 to 2.0 cm in diameterAlmost exclusively located in the corpus and fundus. Histology: Erosions may have only subtle features eg. thin, regenerative epithelium provides the only evidence for their occurrence.Inflammation is usually slight (consisting of no more than a few neutrophils) or absent. Treatment and prevention:Discontinuation of the offending agent.Antisecretory therapy-often used to limit concomitant damage from acid exposure.Prophylaxis- eg antisecretory sometimes used to prevent stress ulceration in the intensive care unit , and for those undergoing chemotherapy. Acute haemorrhagic and Erosive Gastropathy This permits acid and other luminal substances (eg. proteases and bile acids) to penetrate into the lamina propria, where they cause additional injury to the vasculature, stimulate nerves, and cause the release of histamine and other inflammatory mediators Written by Dr Sebastian Zeki

Related Stories

•Gut Microbiota and Metabolome Dynamics Along Gastric Cancer Progression: An Exploratory Multi-Omics Analysis

•Efficacy and safety of adjunctive Chinese herbal decoction in treating Helicobacter pylori-positive chronic atrophic gastritis: a real-world retrospective study

•Vitamin D Deficiency and Replacement Challenges in Type 1 Gastric Neuroendocrine Tumors: A Comparative Study

•Intramuscular Cyanocobalamin Treatment in Patients with Corpus Atrophic Gastritis and Vitamin B(12) Deficiency: Efficacy and Predictors of Increased Requirement-A Monocentric Longitudinal Real-Life Cohort Study

•Molecular Insights into Helicobacter pylori-Induced Gastritis and Gastric Cancer