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Fundic Gland Polyps
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Written by Dr Sebastian Zeki
MCQs for this page
Fundic Gland Polyps
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Clinical features
Regression of fundic gland polyps has also reported with H.pylori infection.
Presence of fundic gland polyps virtually excludes the presence of H.pylori infection.
Fundic Gland Polyps
FAP related fundic gland
polyps
80% of patients with FAP and
attenuated variants of FAP have
these polyps.
They are equally common in
males and females.
They are multiple in >90 %.
Consider FAP if fundal gland
polyps are found and the patient
is not taking PPIs.
Dysplasia occurs in 20% polyps
(assoc. with APC mutations in
polyps).
Sporadic fundal gland polyps
These are more common in females.
The polyps occur in middle age.
Up to 40 % of patients have multiple
polyps.
Pathology
The polyps are composed of normal gastric corpus-
type epithelium, arranged in a disorderly and/or micro
-
cystic configuration.
Microcysts are characteristic, and are lined by any of
the normal cell types found in the gastric corpus.
The glandular compartment typically reveals distorted
architecture with irregular gland buds, tortuous glands,
or irregular stellate glandular configurations.
Inflammation is usually minimal.
Mild hyperplasia of the muscularis mucosa may occur
in a pericystic configuration.
The polyps probably arise from proliferation and
differentiation of aberrantly located proliferative cells
in the stem cell compartment of the corpus epithelium.
Endoscopic Features
They are small (0.1 to 0.8 cm), hyperemic, sessile, flat,
nodular lesions that have a smooth surface contour.
They occur exclusively in the gastric corpus.
They are associated with PPIs.
Written by Dr Sebastian Zeki
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