SAVED
File name .JPG
File alt. text
Image should be px wide x px tall.
Select Image
home - Small Bowel - Small Bowel Masses - Small bowel GIST Written by Dr Sebastian Zeki

Small bowel GIST

GIST (gastrointestinal stromal tumour-most common cause of thickened folds) Clinical Pres: Overt GI bleeding — 40 percent Abdominal mass — 40 percent Abdominal pain — 20 percent Sites:Stomach (50 percent) Small bowel (25 percent) Colon (10 percent),Omentum/mesentery (7 percent),Oesophagus (5 percent) Pathogenesis:: Interstitial cells of Cajal80% have ckit mutations, some of rest have PDGFRA mutations Work up: CT EUS and biopsy- C-kit stain on biopsy specimen PET- only for definitively unresectable or metastatic GISTs Endoscopy: broad base polyp with central ulceration 50% have intragastric component Malignant potential: size/mitotic count/miss sense mutation in C-kit gene Treatment: surgery with adjuvant treatment (high recurrence rate). Glivec if advanced If more than 2cm for resection

Related Stories

•Large Pancreatic Gastrointestinal Stromal Tumor: A Diagnostic Quandary

•Massive gastrointestinal stromal tumor with exophytic growth mimicking pelvic leiomyosarcoma: a case report and review of the literature

•Small bowel lymphatic malformation: Clinical presentation and a comprehensive literature review

•Divergent manifestations and management of GISTs of the small intestine: a case series

•Multifocal small bowel gastrointestinal stromal tumor causing perforation peritonitis: A rare cause of acute abdomen