SAVED
File name .JPG
File alt. text
Image should be px wide x px tall.
Select Image
home - Nutrition - Minerals - Copper Written by Dr Sebastian Zeki

Copper

Acute: GI upset If severe: Cardiac and renal failure, hepatic necrosis, encephalopa-thy, and ultimately death. Albumin amino acids Copper Proximal small intestine Ferroportin Hephaestin Metalloreductase Cu2+ Cu1+ Ctr1 ATP7A (active removal) Cu1+ Secretory path Copper is incorporated into caeruloplasmin (also an acute phase reactant and transported to the peripheriesMetallothionein may be used for copper storage. 50% excreted in bile Dietary sources:Vegetables -20%.Grains -20%.Pulses (leguminous seeds such as beans, peas, and lentils)-20 %.Meat (esp liver), fish, and poultry- 20%. Enzymes:Zinc-copper superoxide dismutase (antioxidant defense)Dopamine mono-oxygenase (neurotransmitter synthesis)Lysyl oxidase (collagen cross-linking, bone formation)Ceruloplasmin (copper transporter and ferroxidase)Cytochrome c oxidase (electron transport)Factor V (thrombosis) Tyrosinase (melatonin production) Neurological abnormali-ties (ataxia, neuropathy and cognitive deficits- similar to B12 deficiency)Fragile, abnormally-formed hairDepigmentation of the skinMuscle weaknessHepatosplenomegalyHematological findings: Microcytic anemia Neutropenia ThrombocytopeniaOsteoporosisOedema ? Acquired Deficiency Risk factors:Premature infants receiving milk formulas.Chronic diarrhoea.Chronic peritoneal dialysis.Zinc supplements.Prior foregut surgery, including gastrectomy. ATP7A gene mutation X-linked Copper deficiency with progressive neurologic deterioration and death during early childhood. "Kinky" hair, Growth retardation, Hypopigmentation of the skin, Bony abnormalities (osteoporosis and spur) Treatment: iv copper-histidine complex. Copper Congenital Deficiency Menke’s kinky hair disease Toxicity Biological role Written by Dr Sebastian Zeki

Related Stories

•Letter to the editor: Effects of an increased habitual dietary protein intake followed by resistance training on fitness, muscle quality and body composition of seniors

•The Possible Role of Selected Vitamins and Minerals in the Therapeutic Outcomes of Leishmaniasis

•Association between macronutrients intake distribution and bone mineral density

•Impact of Micronutrient Supplementation on Pesticide Residual, Acetylcholinesterase Activity, and Oxidative Stress Among Farm Children Exposed to Pesticides

•Incomplete recovery of bone strength and trabecular microarchitecture at the distal tibia 1 year after return from long duration spaceflight