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home - Colon - Colorectal and Anal Cancer - Hyperplastic Polyps Written by Dr Sebastian Zeki

Knows the pathology of benign and malignant tumours of the colon
and rectum
Has awareness of the molecular genetics of colorectal
carcinogenesis and the adenoma-carcinoma sequence
Knows the range of predisposing conditions including inherited
syndromes and acquired colonic diseases
Knows the range of clinical presentation and the means of
diagnosis, investigation, management and follow-up
Knows the strategy for prevention including procedures for

Uses clinical assessment and selects investigations to reach a rapid
conclusion as to whether a patient might have colorectal cancer and
arranges timely investigation.
Refers the patient to the multi-disciplinary team CbD, mini-CEX,

Shows ability to react to possible diagnosis of malignancy in a timely

Communicates with patient and family in a sympathetic and
understanding manner, explains next steps, involves other health
professionals (including the GP) as appropriate

Hyperplastic Polyps

Clinical featuresThe polyp revalence increases in chronic inflammatory conditions, such as chronic atrophic gastritis, PA, and, particularly, postgastrectomy gastritis.The polyps occur mid to late adult life.These occur in males and females with equal incidence.They are predominantly antral but can occur anywhere. Oedematous, congested and actively and chronically inflamed lamina propria Dysplasia Polyps are occasionally dysplastic if >2cm or multiple.The dysplasia incidence is 3%. PathogenesisPolyps are due to chronic inflammation causing hyperregenerative epithelium.The polyps can regress, remain stable, or increase in size. Hyperplastic polyps HistologyThe polyps are elongated, dilated, and/or cysticPolyps are architecturally distortedThere is foveolar epithelium. (75.6 % of polyps- more common than fundic in areas of low H. pylori prevalence) — Written by Dr Sebastian Zeki TreatmentThese can be excisedH. pylori treatment sometimes causes regression.

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